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A review of the literature suggests that the use of NRT in high doses may be associated with a slight increase in the efficacy of the treatment.33,34,39 The use of an appropriate NRT in high doses should be carried out in specialized clinics with pre-treatment and post-treatment monitoring of blood nicotine levels, and with highly dependent smokers who have failed in previous attempts in which they used NRT at the usual doses.1,6,8-15,33,34,80,81 Harm Reduction
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